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Jet Lag Disorder | Yellow Book
Last Updated: Apr 2025
In the American Academy of Sleep Medicine (AASM) clinical practice guidelines for circadian rhythm sleep disorders, standard treatment for jet lag disorder in frequent travelers includes timed melatonin administration; additional…Read more
Melatonin is regulated by the Food and Drug Administration (FDA) as a dietary supplement. Various synthetic melatonin preparations are widely available over the counter (OTC) in the United States with sales increasing…Read more
Normally, the body increases melatonin level in the evening 1 to 2 hours before usual bedtime. Melatonin level peaks in the body around 2-4 a.m. and then decreases until morning, when production ceases. If you take melatoninRead more
Approximately one half (52.4%) of all estimated ED visits for melatonin ingestion by infants and children aged ≤5 years involved children aged 3–5 years, and most (93.5%) did not result in hospitalization. Melatonin was…Read more
Learn more about safe, evidence-based complementary health practices for international travelers.Read more
In this study, we evaluated the effectiveness of experimental lighting interventions in terms their effects on the participants’ levels of the hormone melatonin, which is produced in darkness and prepares the body for sleep.…Read more
They also suggest that “women with previous or current breast cancer be advised not to work night shifts because of strong experimental evidence demonstrating accelerated tumor growth by suppression of melatonin secretion.”…Read more
Circadian disruption means our circadian rhythms are not working together, which can make us feel ill, increase our risk for poor health, and increase our chances for making mistakes that risk our safety and the safety of others. The…Read more
Children are at increased risk for melatonin exposure because of the supplement’s widespread use and growing popularity as a sleep aid. In 2020, melatonin became the most frequently ingested substance among chil- dren…Read more
At least half of ED visits for melatonin ingestions involved flavored products (gummies or chewable tablets) that are frequently used by (4) and might appeal to young children. Melatonin products do not require child-resistant…Read more

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